Vitamins and Neurodegeneration

This book examines the neurobiological impact of vitamins in the pathophysiology and prevention of neurodegenerative diseases, offering an integrative perspective on nutritional modulation of brain health. It explores the antioxidant, anti‑inflammatory, and neurotrophic mechanisms of vitamins, alongside their pharmacokinetics, bioavailability, and blood–brain barrier transport. With a focus on age‑associated deficiencies, impaired absorption, and cognitive decline, it highlights mechanistic links between micronutrient status and neuronal integrity. It also investigates synergistic interactions with cofactor minerals, polyunsaturated fatty acids, and polyphenols, as well as the influence of gut microbiota on vitamin‑mediated neuroprotection. Specific emphasis is placed on the therapeutic implications of vitamins in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and multiple sclerosis (MS).

Key Features:
Explores the neuroprotective and cognitive benefits of essential vitamins, including A, C, E, B complex, D, and K Examines pharmacokinetics, bioavailability, and blood–brain barrier transport mechanisms relevant to vitamin efficacy Analyzes the epidemiology of vitamin deficiency, aging‑related malabsorption, and their link to cognitive impairment Highlights nutrient–nutrient and vitamin–drug interactions in neurological health and therapy Provides disease‑specific insights into the role of vitamins in Alzheimer’s disease, Parkinson’s disease, ALS, Huntington’s disease, and MS
This book is intended for researchers and students of neuroscience and nutritional sciences.