En 1816, sur les bords du Lac Léman, la jeune Mary Shelley s'éprend du médecin de Lord Byron, l'incroyable John Polidori. Ce dernier a réussi, avec le lieutenant Joseph Burton et le docteur Robert Darwin, à perfectionner les expériences d'Aldini : redonner la vie à des tissus morts en y diffusant un courant électrique. Mais lorsque Mary le rejette, Polidori sombre dans la folie…
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